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Andrew Mayne served as OpenAI’s Science Communicator and was its first Prompt Engineer, contributing to GPT-3, ChatGPT, and GPT-4. Andrew is currently the host of The OpenAI Podcast, where he hosts a series of honest, long-form conversations with the people building and shaping technology from inside OpenAI. He is also now the founder of Interdimensional, a firm that helps companies utilize artificial intelligence.
Prior to working at OpenAI, Andrew swam with great white sharks in the Discovery Channel special Andrew Mayne: Ghost Diver.
Andrew is a Wall Street Journal bestselling novelist. He has been nominated for the Edgar Award for his book Black Fall and the Thriller Award for Name of the Devil and The Naturalist – an Amazon Charts best-seller that spent six weeks at the number one spot for all books on Amazon. Prior to his first publishing deal, Andrew was listed by Amazon as one of the top 10 bestselling indie authors of the year.
Andrew also starred in the A&E magic television series Don’t Trust Andrew Mayne.
With the support from the Johnny Carson Foundation and the James Randi Educational Foundation, Andrew created a program to use magic to teach critical thinking skills in public schools. His Wizard School segments, teaching magic and science to children, aired nationwide on Public Television.
As a creative consultant, he’s worked behind the scenes for David Copperfield, Penn & Teller, and David Blaine. He’s developed innovative magic effects that are performed around the world and even helped develop an experiment that was conducted onboard the International Space Station.
His underwater stealth suit featured in the Shark Week special, Andrew Mayne: Ghost Diver, was the result of his interest in perception and engineering. While researching great white sharks and their behavior, he developed artificial intelligence models based on sharks and used them to create a VR training simulator for shark interaction.
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Before AI went mainstream, Andrew Mayne was an outsider—an author and magician exploring the edges of human creativity. That same curiosity led him inside OpenAI, where he became the company’s first prompt engineer and helped shape the way humans and machines think together. In this talk, he shares lessons from inside one of the world’s most influential AI labs: how to recognize inflection points before they happen, turn uncertainty into momentum, and build a career that thrives through technological upheaval. It’s a roadmap for anyone, from executives to creators, who wants to navigate the AI revolution not as a passenger, but as a pilot.
A decade ago, Andrew Mayne bet his career on artificial intelligence—and watched it evolve from a lab curiosity into the defining force of our time. From the inside of OpenAI to the frontlines of startup innovation, he has seen how quickly the future arrives and who actually captures its value. In this talk, Mayne offers a grounded look at where AI is going next—what’s real, what’s noise, and what leaders need to prepare for now. It’s an insider’s guide to navigating the next wave of intelligence, from models to markets to mindsets.
From OpenAI to Interdimensional, Andrew Mayne has seen firsthand what separates companies that talk about AI from those that win with it. This session reveals how to build and lead teams that amplify human capability with intelligent tools—where small, focused groups can out-innovate entire industries. He breaks down the playbook for assembling AI-literate teams, integrating models into real workflows, and fostering a culture where experimentation drives measurable growth.
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